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VSIG4 Monoclonal Antibody (NLA14), Alexa Fluor™ 488, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 53-5752-82

306.85 EUR gültig bis 2024-03-29
Benutzen Sie den Promotions-Code "21653" um Ihren Promotions-Preis zu erhalten.



Weitere Details : Netto-Gewicht : 0.01000kg

Artikelnummer. 16340994

  • 361.00 € / 100 Mikrogramm
Verfügbar ab: 22-04-2024
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Beschreibung

Beschreibung

Description: This NLA14 monoclonal antibody recognizes mouse V-Set and Immunoglobulin domain containing 4 (VSIG4), also known as Complement Receptor of the Immunoglobulin superfamily (CRIg) or Z39Ig. VSIG4 is a type I transmembrane glycoprotein structurally related to the B7 family of immune regulatory proteins. It contains one complete V-type Ig domain and one truncated C-type Ig domain. VSIG4 is exclusively expressed on tissue resident and tumor infiltrating macrophages. It has been shown to bind complement components C3b and iC3b. This binding inhibits the alternative complement pathway and facilitates phagocytosis of complement-opsonized pathogens. VSIG4 has also been reported to suppress T cell activation, proliferation and IL-2 production thereby playing a role in the maintece of peripheral T cell tolerance and suppression of established inflammation. Expression of VSIG4 on tumor-infiltrating macrophages suggests its role in immune evasion. Pro-inflammatory stimuli such as TNF and LPS have been reported to down-regulate the expression of VSIG4. Peritoneal macrophages in Balb/c mice express significantly higher levels of VSIG4 than such macrophages in C57Bl/6 or Swiss Webster mice. The NLA14 antibody will recognize VSIG4 on cells that have been formaldehyde-fixed and permeabilized. This antibody does not block the ligation of VSIG4 to its T cell ligand. The NLA14 antibody does not cross-react with rat or human VSIG4.

VSIG4 Monoclonal antibody specifically detects VSIG4 in Mouse samples. It is validated for Flow Cytometry.
Spezifikation

Spezifikation

VSIG4
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
0
VSIG4
Affinity chromatography
RUO
278180
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
NLA14
Alexa Fluor 488
VSIG4
A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG
Rat
100 μg
Primary
Mouse
Antibody
IgG2a κ
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote