Tocris Bioscience™ WWL 113

Beschreibung

Carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ∽100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.