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YM 298198 hydrochloride, Tocris Bioscience™

Highly potent, selective non-competitive mGlu1 antagonist

Marke:  Tocris (Bio-Techne) 244810

Weitere Details : Netto-Gewicht : 0.01000kg

Menge. 10mg

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Artikelnummer. 13411234

  • 294.00 € / 10 Milligramm

Voraussichtlicher Liefertermin 22-10-2019

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Beschreibung

Beschreibung

Non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM); inactive at other mGlu receptor subtypes (mGlu2-7), ionotropic receptors and glutamate transporters (IC50 > 10 μM). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC50 values are 16 nM and 6.3 μM respectively), and is orally active in vivo, demonstrating an antinociceptive effect in hyperalgesic mice.

Desmethyl Derivative also available.

Spezifikation

Chemische Identifikatoren

1216398-09-2
378.919
ym 298198 hydrochloride, 6-amino-n-cyclohexyl-n,3-dimethylthiazolo 3,2-a benzimidazole-2-carboxamide hydrochloride, ym-298198 hydrochloride hplc, thiazolo 3,2-a benzimidazole-2-carboxamide,6-amino-n-cyclohexyl-n,3-dimethyl, 11-amino-n-cyclohexyl-n,3-dimethyl-5-thia-2,7-diazatricyclo 6.4.0.0_,? dodeca-1 12 ,3,6,8,10-pentaene-4-carboxamide hydrochloride, 6-amino-n-cyclohexyl-n,3-dimethyl 1,3 thiazolo 3,2-a benzimidazole-2-carboxamide-hydrogen chloride 1/1
7-amino-N-cyclohexyl-N,1-dimethyl-[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide;hydrochloride
C18H23ClN4OS
WYTJVUVCSUWZTH-UHFFFAOYSA-N
45073464
CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl

Spezifikation

10mg
1216398-09-2
ym 298198 hydrochloride, 6-amino-n-cyclohexyl-n,3-dimethylthiazolo 3,2-a benzimidazole-2-carboxamide hydrochloride, ym-298198 hydrochloride hplc, thiazolo 3,2-a benzimidazole-2-carboxamide,6-amino-n-cyclohexyl-n,3-dimethyl, 11-amino-n-cyclohexyl-n,3-dimethyl-5-thia-2,7-diazatricyclo 6.4.0.0_,? dodeca-1 12 ,3,6,8,10-pentaene-4-carboxamide hydrochloride, 6-amino-n-cyclohexyl-n,3-dimethyl 1,3 thiazolo 3,2-a benzimidazole-2-carboxamide-hydrogen chloride 1/1
CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl
378.919
378.92
YM 298198 hydrochloride
C18H23ClN4OS
WYTJVUVCSUWZTH-UHFFFAOYSA-N
7-amino-N-cyclohexyl-N,1-dimethyl-[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide;hydrochloride
45073464
>99%
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