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1,1-Dimethylbiguanide hydrochloride

Product Code. 15495609
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Product Code. 15495609 Supplier Thermo Scientific Alfa Aesar Supplier No. J63361.14
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Description

An antidiabetic agent | CAS: 1115-70-4 | C4H12ClN5 | 165.63 g/mol

1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1

• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes

• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells

• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway

• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders

• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1115-70-4
Summenformel C4H12ClN5
Molekulargewicht (g/mol) 165.63
MDL-Nummer MFCD00012582
InChI-Schlüssel OETHQSJEHLVLGH-UHFFFAOYSA-N
Synonym metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
PubChem CID 14219
IUPAC-Name Wasserstoff-1-[(Diaminomethyliden)amino]-N,N-dimethylmethanimidamid-chlorid
SMILES [H+].[Cl-].CN(C)C(=N)N=C(N)N

Specifications

Chemischer Name oder Material 1,1-Dimethylbiguanide hydrochloride
Schmelzpunkt 218°C to 226°C
Farbe Weiß
Strukturformel NH2C(=NH)NHC(=NH)N(CH3)2·HCl
Menge 25 g
Merck Index 14,5938
Löslichkeitsinformationen Soluble in water (50mg/ml),ethanol,and DMSO (50 mM).
Formelmasse 165.62
Physikalische Form Pulver

RUO – Research Use Only

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