Invitrogen™ alpha Actinin 2 Recombinant Rabbit Monoclonal Antibody (HL1692)

Beschreibung

alpha Actinin 2 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it i involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.