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β-Catenin Mouse, Alexa Fluor 488, Clone: 14/Beta-Catenin, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 562505
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Beschreibung
The 14/Beta-Catenin monoclonal antibody specifically binds to Beta-Catenin ( β -Catenin). β -Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function. Although the α - and β -Catenins have been cloned, very little is known about their biochemical roles. However a link between β -Catenin and colon cancer has been described. β -Catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was not detectable in these complexes. Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion.
Spezifikation
| β-Catenin | |
| Monoclonal | |
| Alexa Fluor 488 | |
| Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. | |
| Mouse β-Catenin aa. 571-781 | |
| 100 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| In vitro Assay, Immunofluorescence | |
| 14/Beta-Catenin | |
| CTNNB1; CTNB1; Catenin beta-1; catenin (cadherin-associated protein) beta 1 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human, Mouse | |
| IgG1 |
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