CD119 Hamster anti-Mouse, Biotin, Clone: 2E2, BD

The 2E2 antibody recognizes the extracellular region of the 90 kDa alpha chain subunit of the mouse interferon- γreceptor (IFN- γR α ; aka , CD119). The functionally active-form of the mouse IFN- γreceptor consists of two (or more) subunits, with IFN- γγR α and IFN- γR β chains required for the transduction of biologic responses. IFN- γR α is expressed by a variety of cell lines and normal mouse cells (except mature erythrocytes) including T cells, B cells, NK cells, monocytes, neutrophils, fibroblasts, epithelial and endothelial cells. The 2E2 antibody is a non-neutralizing antibody; it does not block the binding of IFN- γto its receptor. The immunogen used to generate this hybridoma was a purified preparation of soluble recombinant mouse IFN- γR α chain protein.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.