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CD274 Mouse anti-Human, Brilliant Violet 786, Clone: MIH1, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 563739
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Beschreibung
The MIH1 monoclonal antibody specifically binds to CD274, also known as Programmed Death Ligand 1 (PD-L1) and B7 Homolog 1 (B7-H1). CD274/PD-L1 and CD273/PD-L2 are members of the B7 family within the Immunoglobulin superfamily. These type I transmembrane glycoproteins function as ligands for CD279, likewise known as the Programmed Death 1 (PD-1) receptor. CD274 is expressed on activated dendritic cells, macrophages and T cells. Studies show some overlapping functions of CD274 and CD273 and indicate an important role for CD279 and its ligands in regulating T and B cell responses. CD274 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, keratinocytes, and carcinomas. The MIH1 antibody is reportedly a blocking antibody.
The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. This dye is a tandem fluorochrome of BD Horizon™ BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 786-nm. BD Horizon™ BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60-nm filter).
Spezifikation
| CD274 | |
| Monoclonal | |
| Brilliant Violet 786 | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Human B7-H1 Transfected Cell Line | |
| 100 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| MIH1 | |
| B7-H1; Programmed death ligand 1; PD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human | |
| IgG1 κ |
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