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Clec12A Mouse anti-Human, PE, Clone: 50C1, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 562566
Beschreibung
The 50C1 monoclonal antibody specifically binds to human Clec12A (C-type lectin domain family 12 member A). Clec12A is also known as myeloid inhibitory C-type lectin-like receptor (MICL), C-type lectin-like molecule 1 (CLL-1) or dendritic cell-associated lectin 2 (DCAL-2). It is expressed on a variety of cells including monocytes, macrophages, dendritic cells, and granulocytes and perhaps some NK cells. Cleck12A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. It is a 30kDa type II transmembrane glycoprotein that has one single C-type lectin-like domain and one cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). Clec12A has similarity with the β-glucan receptor (Dectin-1) and LOX-1 with high N-glycosylation. There are at least five isoforms due to alternative transcript splicing. Signaling through Clec12A can induce internalization of Cleck12A, dendritic cell maturation and the production of cytokines including IL-12. Clec12A may also serve as a negative regulator of activated leukocytes recruited to sites of inflammation.
Host Species: Mouse
Clone: 50C1
Isotype: IgG2a, κ
Species Reactivity: Human
Immunogen: Human CLEC12A Transfected Cell Line
Flow Cytometry
Spezifikation
| Clec12A | |
| Monoclonal | |
| PE | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Human CLEC12A Transfected Cell Line | |
| 50 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| 50C1 | |
| CD371; Clec12A; MICL; CLL-1; DCAL-2 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human | |
| IgG2a κ |
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