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IκBα Mouse anti-Human, Unlabeled, Clone: 25, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 610690
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Beschreibung
NF-κB is a transcription factor that regulates many cytokine and Ig genes involved in immune response, inflammation, and viral infections. NF-κB is induced by cytokines and lipopolysaccharide (LPS), but is inhibited by glucocorticoids. IκBα/MAD-3 inhibits the DNA-binding activity of NF-κB and related transcription factors. In THP-1 monocytic-like cells, LPS induces the phosphorylation and inactivation of IκBα, which results in the activation of NF-κB. Therefore, phosphorylation of IκBα may induce the dissociation of the IκBα/NF-κB complex.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Spezifikation
| IκBα | |
| Monoclonal | |
| 250μg/mL | |
| MAD-3; I-kappa-B-alpha; IkB-alpha; NFKBIA; NF-kappa-B inhibitor alpha | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
| Western Blot | |
| 25 | |
| Unconjugated | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Human IκBα aa. 145-302 | |
| 50 μg | |
| Cell Biology | |
| Human | |
| IgG1 |
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