ID3 Mouse, PE, Clone: S30-778, BD

The S30-778 monoclonal antibody specifically binds to Inhibitor of DNA binding 3 (ID3). ID3 is one of four ID proteins (ID1-4) that have been characterized in humans. It is also known as Class B basic helix-loop-helix protein 25 (BHLHB25), Helix-loop-helix protein HEIR-1, and ID-like protein inhibitor HLH 1R21. ID3 is a Helix-Loop-Helix (HLH) protein that can form heterodimers with other HLH transcription factors such as MyoD, myogenin, E12 and E47. These latter transcription factors normally regulate the development, differentiation and functions of a variety of cell types including muscle cells, and subsets of T and B cells. Because it lacks a basic DNA-binding domain, ID3 can inhibit the DNA binding and function of these other transcription factors it complexes with. Abnormal ID3 expression has been associated with certain cancers. The S30-778.8.66 antibody crossreacts with mouse Id3.