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PNAd Carbohyde Epitope Rat anti-Mouse, Unlabeled, Clone: MECA-79, BD
Rat Monoclonal Antibody
Marke: BD Biosciences 553863
Beschreibung
The MECA-79 antibody reacts with sulfate-dependent carbohydrate epitopes of peripheral lymph node addressin (PNAd). The MECA-79-reactive antigen is closely associated with the carbohydrate ligands for L-selectin (eg, CD34, GlyCAM-1, MAdCAM-1), which are expressed on high endothelial venules (HEV) in lymphoid tissues and at sites of chronic inflammation. Cross-reactivity with human, sheep, cow, primate, and pig tissues has been observed. MECA-79 antibody inhibits L-selectin-dependent lymphocyte and platelet homing to lymph nodes in vivo, and in vitro adhesion to lymphoid tissue HEV and immobilized PNAd.
Host Species: Rat
Clone: MECA-79
Isotype: IgM, κ
Species Reactivity: Mouse
Immunogen: Collagenase-dispersed BALB/c lymph node stroma
Immunohistochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blotting
Spezifikation
| PNAd Carbohyde Epitope | |
| Monoclonal | |
| 0.5mg/mL | |
| CD62L Ligand | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C |
| Immunohistochemistry (Paraffin) | |
| MECA-79 | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Collagenase-dispersed BALB/c lymph node stroma | |
| 0.5 mg | |
| Cell Biology | |
| Mouse | |
| IgM κ |
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For Research Use Only.