Invitrogen™ ATG11 Monoclonal Antibody (7C2NB)

ATG11 (Autophagy-Related Gene 11) is a key gene involved in the autophagy process, a cellular degradation and recycling system that is crucial for maintaining cellular homeostasis. Autophagy allows cells to break down and reuse damaged organelles, misfolded proteins, and other cellular debris, especially under conditions of stress or nutrient deprivation. ATG11 encodes a scaffold protein that plays a pivotal role in selective autophagy by facilitating the recruitment and organization of autophagy machinery components to the phagophore assembly site. It is particularly important in the selective degradation of specific organelles, such as peroxisomes (pexophagy) and mitochondria (mitophagy), as well as in the removal of protein aggregates. Dysfunction or mutations in ATG11 can disrupt autophagic processes, leading to the accumulation of cellular waste and contributing to various pathological conditions, including neurodegenerative diseases like Parkinson's and Alzheimer's, as well as certain cancers. Understanding the function and regulation of ATG11 is essential for developing therapeutic strategies aimed at enhancing autophagy to treat these diseases. Research into ATG11 continues to provide valuable insights into the mechanisms of selective autophagy and its broader implications for cellular health and disease management.