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Invitrogen™ AXIN2 Recombinant Rabbit Monoclonal Antibody (3G6)
Rabbit Recombinant Monoclonal Antibody
Marke: Invitrogen™ MA560621
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Beschreibung
AXIN2 Recombinant Monoclonal Antibody for ELISA
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Spezifikation
| AXIN2 | |
| Recombinant Monoclonal | |
| 3 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q9Y2T1 | |
| AXIN2 | |
| A synthesized peptide derived from human AXIN2. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
| ELISA | |
| 3G6 | |
| Unconjugated | |
| AXIN2 | |
| Axi1; axil; axin 2; Axin like protein; axin2; axin-2; Axin-like protein; Axis inhibition protein 2; conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 8313 | |
| -20°C or -80°C if preferred | |
| Liquid |
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