Invitrogen™ BEND2 Polyclonal Antibody

Beschreibung

Immunogen sequence: DQDDASASAC LTPDFALLPL NILVKVDTNT ENSVNTMNRS TLLDSDSGQD SSSSSVCIPP KYGYLGDPKR NVRVLKIHLL AVQNMAKPKQ AACYLVRILF SKEILISSSV DIHLKDSQSL DPNKMAALRE YLATTFPTCD LHEHG Highest antigen sequence identity to the following orthologs: Mouse - 32%, Rat - 21%.

The BEND2 gene, located on chromosome Xp22.2, encodes a protein that is part of the BEN domain-containing family, which is implicated in chromatin organization and transcriptional regulation. BEND2 is critical in spermatogenesis, particularly in the meiotic phase of germ cell development. Knockout studies in male mice have shown that loss of BEND2 disrupts the transition from zygonema to pachynema, interferes with chromosomal synapsis, and impairs the repair of DNA double-strand breaks, ultimately causing infertility. Additionally, BEND2's interaction with chromatin-associated proteins suggests its role in the formation of transcription-repressor complexes, essential for proper gene expression regulation during meiosis.