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Capsazepine, 98+%

Artikelnummer. 15415329
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Artikelnummer. 15415329 Lieferant Thermo Scientific Alfa Aesar Lieferanten-Nr. J63055.MF
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Verfügbar ab: 08-10-2026
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Beschreibung

A competitive antagonist for capsaicin and resiniferatoxin | CAS: 138977-28-3 | C19H21ClN2O2S | 376.899 g/mol

Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin (sc-24015)- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin (sc-24015)- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin.

Solubility
Soluble in ethanol or DMSO

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 138977-28-3
Summenformel C19H21ClN2O2S
Molekulargewicht (g/mol) 376.899
MDL-Nummer MFCD00153778
InChI-Schlüssel DRCMAZOSEIMCHM-UHFFFAOYSA-N
Synonym capsazepine, capsazepin, n-2-4-chlorophenyl ethyl-1,3,4,5-tetrahydro-7,8-dihydroxy-2h-2-benzazepine-2-carbothioamide, unii-lfw48my844, n-2-4-chlorophenyl ethyl-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide, 2-2-4-chlorophenyl ethylamino-thiocarbonyl-7,8-dihydroxy-2,3,4,5-tetrahydro-1h-2-benzazepine, n-2-4-chlorophenyl ethyl-7,8-dihydroxy-1,3,4,5-tetrahydro-2h-2-benzazepine-2-carbothioamide, capasazepine, tocris-0464
PubChem CID 2733484
ChEBI CHEBI:70773
IUPAC-Name N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide
SMILES C1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O

Spezifikation

Chemischer Name oder Material Capsazepine
Schmelzpunkt 159°C to 161°C
Farbe Weiß
Menge 50 mg
Löslichkeitsinformationen Soluble in ethanol or DMSO
Formelmasse 376.9
Reinheit (%) ≥99%
Physikalische Form Pulver

RUO – Research Use Only

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