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Invitrogen™ Carbonic Anhydrase IX Polyclonal Antibody
Rabbit Polyclonal Antibody
Marke: Invitrogen™ PA586519
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Beschreibung
Purity is > 95% by SDS-PAGE.
Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
Spezifikation
| Carbonic Anhydrase IX | |
| Polyclonal | |
| Unconjugated | |
| CA9 | |
| Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 230099, 313495, 768 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q16790, Q8VHB5 | |
| CA9, Car9 | |
| Synthetic peptide, corresponding to amino acids 50-104 of Human CA IX. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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