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Invitrogen™ CCL5 (RANTES) Recombinant Superclonal™ Antibody (25HCLC)

Artikelnummer. 15397134
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Menge:
100 μg
Packungsgröße:
100 Mikrogramm
Artikelnummer. Menge unitSize
15397134 100 μg 100 Mikrogramm
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Artikelnummer. 15397134

Marke: Invitrogen™ 710001

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Beschreibung

Rabbit Recombinant Superclonal Antibody

This antibody is predicted to react with rat and human based on sequence homology. Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called 'Recombinant polyclonal antibody', this product is now rebranded as 'Recombinant Superclonal™ antibody'. The physical product and the performance remain unchanged.

CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen CCL5 (RANTES)
Anwendungen Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Klassifikation Recombinant Superclonal
Klon 25HCLC
Konzentration 0.5 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with 0.09% sodium azide
Gen CCL5
Gen-Zugriffsnummer P13501, P30882, P50231
Gen-Alias beta-chemokine RANTES; CC chemokine; C-C motif chemokine 5; C-C motif chemokine ligand 5; CCL5; chemokine (C-C motif) ligand 5; D17S136E; EoCP; eosinophil chemotactic cytokine; MGC17164; MuRantes; OTTHUMP00000197106; RANTES; RANTES protein; RANTES(3-68); RANTES(4-68); regulated upon activation normal T-cell expressed and secreted; regulated upon activation, normally T-expressed, and presumably secreted; Scya5; SIS δ; SISd; SIS-delta; SISδ; small inducible cytokine A5; small inducible cytokine subfamily A (Cys-Cys), member 5; small-inducible cytokine A5; T cell-specific protein P228; T-cell specific protein p288; T-cell-specific protein RANTES; TCP228; Unknown (protein for MGC:127014)
Gensymbole CCL5
Wirtsspezies Rabbit
Immunogen proprietary.
Reinigungsverfahren Protein A
Menge 100 μg
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 20304, 6352, 81780
Zielspezies Human, Mouse, Rat
Inhalt und Lagerung Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Produkttyp Antibody
Form Liquid
Isotype IgG
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