Invitrogen™ CD119 (IFN gamma Receptor 1) Monoclonal Antibody (GIR-208 (GIR 208)), Biotin, eBioscience™, Invitrogen™

Beschreibung

Description: The monoclonal antibody reacts with human CD119 also known as the IFN gamma receptor 1 (alpha chain). IFN gamma R1 is found in a complex with IFN gamma receptor beta and recognizes with high affinity IFN gamma. Expression is ubiquitous but low, although some cell types, such as monocytes express higher levels. The GIR-208 monoclonal antibody is blocked from binding when IFN gamma is bound to the receptor. Applications Reported: This GIR-208 (GIR 208) antibody has been reported for use in flow cytometric analysis. Applications Tested: This GIR-208 (GIR 208) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.