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CD25 Rat anti-Mouse, PerCP-Cy5.5, Clone: PC61, BD
Rat Monoclonal Antibody
201.00 € - 484.00 €
Spezifikation
Antigen | CD25 |
---|---|
Klon | PC61 |
Konzentration | 0.2mg/mL |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15890779
|
BD Biosciences
561112 |
25 μg |
201.00 €
1 Stück |
Verfügbar ab: 14-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
15816508
|
BD Biosciences
551071 |
0.1 mg |
484.00 €
1 Stück |
Verfügbar ab: 21-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
The PC61 monoclonal antibody specifically binds to CD25, the low-affinity IL-2 Receptor α chain (IL-2R α , p55) expressed on activated T and B lymphocytes from all mouse strains tested. IL-2R α by itself is not a signaling receptor. However, it can combine with IL-2 Receptor β (CD122) and γc (CD132) chains to form high-affinity, signaling receptor complexes for IL-2. Resting T and B lymphocytes and resting and activated NK cells do not express IL-2R α . CD25 is transiently expressed at a low level during normal B-cell development in the bone marrow on the CD45R/B220low TdT- sIg- Pre-B/Pre-B-II and CD45R/B220low TdT- sIgM+ sIgD- immature B stages, but not on the CD45R/B220low TdT+ sIg- Pro-B/Pre-B-I stage nor on CD45R/B220high TdT- sIgM+ sIgD+ mature B cells. It is expressed at a higher level during a very early stage of T-cell development in fetal and adult thymus. Peripheral CD25+CD4+ lymphocytes called regulatory T (Treg) cells are involved in the maintenance of self-tolerance. It has also been reported that dendritic cells express CD25, recognized by mAb 7D4 (Cat. No. 553068). The PC61 antibody recognizes an epitope of CD25 which is distinct from the IL-2 binding site and from those recognized by mAbs 3C7 (Cat. No. 557364) and 7D4 (Cat. No. 553068). It blocks binding of IL-2 to CD25, presumably by inducing a conformational change in CD25.
Spezifikation
CD25 | |
0.2mg/mL | |
Monoclonal | |
Rat | |
Mouse | |
IL-2-dependent cytolytic mouse T-cell clone B6.1 | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
PC61 | |
Flow Cytometry | |
PerCP-Cyanine5.5 | |
RUO | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
IgG1 λ | |
Affinity Purified | |
Interleukin-2 receptor alpha chain; IL-2RA; IL-2Rα; Il2ra; IL-2R p55 |
For Research Use Only.