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CD28 Hamster anti-Mouse, PE, Clone: 37.51, BD
Hamster Monoclonal Antibody
Marke: BD Biosciences 561789
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Beschreibung
The 37.51 antibody reacts with CD28, which is expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T cells, and at even lower density on NK cells. The expression of CD28, in splenocytes and thymocytes, has been reported to increase after activation. CD28 transcripts are found in mast cells, and cell-surface expression of CD28 is induced upon maturation or activation of mast cells. It has been reported that CD28 is not expressed on some populations of intraepithelial T lymphocytes. CD28 is a costimulatory receptor; its ligands include CD80 (B7-1) and CD86 (B7-2). The 37.51 mAb augments proliferation and cytokine production by activated T and NK cells and can provide a costimulatory signal for CTL induction. There is considerable evidence that CD28 is a costimulatory receptor involved in many, but not all, T cell-dependent immune responses.
Spezifikation
| CD28 | |
| Monoclonal | |
| 0.2mg/mL | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse EL-4 (T-cell lymphoma) Cells | |
| 25 μg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| 37.51 | |
| PE | |
| Hamster | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgG2 λ1 |
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