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Invitrogen™ CD31 (PECAM-1) Monoclonal Antibody (Gi-34), eBioscience™
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Product Code. 15561317
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Menge:
100 μg
Unit Size:
100 Mikrogramm
Product Code. Menge unitSize
15561317 100 μg 100 Mikrogramm
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Product Code. 15561317

Brand: Invitrogen™ BMS1020

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Description

Mouse Monoclonal Antibody

Description: Recognizes the Ig loops 2-3 of human CD31. PECAM-1 is a transmembrane glycoprotein with a molecular weight of approximately 130 kDa, depending on the degree of glycosylation. PECAM-1 is constitutively expressed on all vascular cells and has provided a useful immunohistochemical marker of blood vessels, particularly in the setting of angiogenesis. It has also been found on platelets, monocytes, neutrophils and CD8+ T cells. Bone marrow stem cells and transformed cell lines of the myeloid and megakaryocytic lineage also express PECAM-1. Interestingly, PECAM-1 was also detected on human, mouse and rat solid tumor lines. Recent studies suggest a role for PECAM-1 in the inflammatory process and leukocyte-endothelial interaction. PECAM-1 is an early and sensitive marker for tumor-induced angiogenesis. Several data have suggested that PECAM-1 may be involved in the process of angiogenesis in a developing vertebrate embryo as well as during metastases formation. Applications Tested: ELISA, Flow Cytometry, Immunoprecipitation, Western Blotting, Monoclonal antibody immobilization of platelet antigens (MAIPA).

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
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Specifications

Antigen CD31 (PECAM-1)
Anwendungen ELISA, Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot, Immunocytochemistry
Klassifikation Monoclonal
Klon Gi-34
Konzentration 1 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with no preservative; pH 7.2-7.4
Gen Pecam1
Gen-Zugriffsnummer P16284
Gen-Alias C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule
Gensymbole Pecam1
Wirtsspezies Mouse
Reinigungsverfahren Affinity chromatography
Menge 100 μg
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 5175
Zielspezies Human
Inhalt und Lagerung -20°C
Produkttyp Antibody
Form Liquid
Isotype IgG1
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