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Invitrogen™ CD4 Monoclonal Antibody (OKT4 (OKT-4)), APC, eBioscience™, Invitrogen™

Artikelnummer. 15577856
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Menge:
100 Tests
25 Tests
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100 Tests
25 Tests
Artikelnummer. Menge unitSize
15577856 100 Tests 100 Tests
15567856 25 Tests 25 Tests
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Artikelnummer. 15577856

Marke: Invitrogen™ 17004842

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Beschreibung

Mouse Monoclonal Antibody

Description: The OKT4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface glycoprotein expressed by the majority of thymocytes, a subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). The OKT4 antibody recognizes a different epitope than the RPA-T4 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. Applications Reported: This OKT4 (OKT-4) antibody has been reported for use in flow cytometric analysis. Applications Tested: This OKT4 (OKT-4) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.06 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen CD4
Anwendungen Flow Cytometry
Klassifikation Monoclonal
Klon OKT4 (OKT-4)
Konzentration 5 μL/Test
Konjugat APC
Zusammensetzung PBS with BSA and 0.09% sodium azide; pH 7.2
Gen CD4
Gen-Zugriffsnummer P01730
Gen-Alias Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
Gensymbole CD4
Wirtsspezies Mouse
Reinigungsverfahren Affinity chromatography
Menge 100 Tests
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 920
Zielspezies Human
Inhalt und Lagerung 4°C, store in dark, DO NOT FREEZE!
Produkttyp Antibody
Form Liquid
Isotype IgG2b κ
Umweltfreundliche Eigenschaften Responsibly packaged
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