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CD54 Hamster anti-Mouse, FITC, Clone: 3E2, BD
Hamster Monoclonal Antibody
Spezifikation
| Antigen | CD54 |
|---|---|
| Klon | 3.00E+02 |
| Konzentration | 0.5mg/mL |
| Anwendungen | Flow Cytometry |
| Klassifikation | Monoclonal |
Beschreibung
The 3E2 antibody reacts with CD54 (ICAM-1), a 95-kDa member of the Ig superfamily found on lymphocytes, vascular endothelium, high endothelial venules, epithelial cells, macrophages, and dendritic cells. ICAM-1 is a ligand for LFA1 (CD11a/CD18) and Mac-1 (CD11b/CD18). Its expression is upregulated upon stimulation by inflammatory mediators such as cytokines and LPS. Studies with mouse Icam1-transfected antigen-presenting cells, with CD54-blocking antibodies, and in CD54-deficient mice indicate that CD54 participates in inflammatory reactions and antigen-specific immune responses. In addition, there is evidence that CD54 is a receptor involved in MHC-non-restricted responses to weakly immunogenic tumor cells. The 3E2 antibody has been reported to block in vitro and in vivo intracellular adhesion events involved in immune responses.
Spezifikation
| CD54 | |
| 0.5mg/mL | |
| Monoclonal | |
| Hamster | |
| Mouse | |
| Not reported | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| 3.00E+02 | |
| Flow Cytometry | |
| FITC | |
| RUO | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| IgG1 κ | |
| Affinity Purified | |
| ICAM-1; Icam1; Intercellular adhesion molecule 1; Ly-47; MALA-2; MyD10 |
For Research Use Only.
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