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Invitrogen™ CD56 (NCAM) Monoclonal Antibody (TULY56), Alexa Fluor™ 660, eBioscience™, Invitrogen™

Artikelnummer. p-7218401
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Menge:
100 Tests
25 Tests
Packungsgröße:
100 Stück
25 Stück
Artikelnummer. Menge unitSize
17116228 25 Tests 25 Stück
17126228 100 Tests 100 Stück
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Artikelnummer. 17116228

Marke: Invitrogen™ 606056641

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Mouse Monoclonal Antibody

Description: The TULY56 monoclonal antibody reacts with human CD56, also known as Neural Cell Adhesion Molecule (NCAM). CD56 is a highly glycosylated transmembrane molecule expressed by neurons and plays a role in the homotypic adhesion of neural cells. In the hematopoietic system, CD56 is expressed on NK cells and a subset of T cells referred to as NKT cells. Staining with TULY56 does not block binding of CMSSB, suggesting that the two antibodies recognize different epitopes. Additionally, TULY56 performs better after fixation and permeabilization than CMSSB. The TULY56 monoclonal antibody crossreacts with Rhesus macaque. Applications Reported: This TULY56 antibody has been reported for use in flow cytometric analysis. Applications Tested: This TULY56 antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Alexa Fluor 660 emits at 690 nm and is intended for use on spectral cytometers where it may be multiplexed with APC, Alexa Fluor 647 and Alexa Fluor 700. Excitation: 662 nm; Emission: 690 nm; Laser: Red Laser

CD56, also known as neural cell adhesion molecule (NCAM), is a highly glycosylated transmembrane glycoprotein of the immunoglobulin family. It plays a crucial role in cell adhesion, migration, axonal growth, pathfinding, and synaptic plasticity. CD56 is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa and is involved in homotypic adhesion of neural cells. It mediates interactions by binding extracellular matrix components such as laminin and integrins, with polysialic modification reducing CD56-mediated adhesion. In the hematopoietic system, CD56 is expressed on natural killer (NK) cells and a subset of T cells known as NKT cells. It is also found on most neuroectodermal-derived cell lines, tissues, and neoplasms, including retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. CD56 serves as a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms, highlighting its importance in both neural and immune system functions.
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen CD56 (NCAM)
Anwendungen Flow Cytometry
Klassifikation Monoclonal
Klon TULY56
Konzentration 5 μL/Test
Konjugat Alexa Fluor 660
Zusammensetzung PBS with BSA and 0.09% sodium azide; pH 7.2
Gen Ncam1
Gen-Zugriffsnummer P13591
Gen-Alias adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; Cd56; CD-56; CD56 120 kDa GPI-linked isoform; CD56 140 kDa isoform; CD56 140 kDa VASE isoform; E NCAM; E-NCAM; MSK39; N CAM1; NCAM; N-CAM; Ncam1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
Gensymbole Ncam1
Wirtsspezies Mouse
Reinigungsverfahren Affinity chromatography
Menge 25 Tests
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 4684, 693789
Zielspezies Human, Monkey, Rhesus Macaque
Inhalt und Lagerung 4°C, store in dark, DO NOT FREEZE!
Produkttyp Antibody
Form Liquid
Isotype IgG1 κ
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