missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Antikörper
  4. Primärantikörper
  5. Alle Primärantikörper
  6. Invitrogen™ CD74 Monoclonal Antibody (VIC-Y1), eBioscience™, Invitrogen™

Invitrogen™ CD74 Monoclonal Antibody (VIC-Y1), eBioscience™, Invitrogen™
GREENER_CHOICE

Artikelnummer. 15207077
Ansicht ändern
Click to view available options
Menge:
100 μg
25 μg
Packungsgröße:
100 Mikrogramm
25 Mikrogramm
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Artikelnummer. Menge unitSize
15207077 100 μg 100 Mikrogramm
15297067 25 μg 25 Mikrogramm
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen
Artikelnummer. 15207077 Lieferant Invitrogen™ Lieferanten-Nr. 14074782

Please to purchase this item. Need a web account? Register with us today!

Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen

Beschreibung

Mouse Monoclonal Antibody

Description: This VIC-Y1 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43 kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NFkB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4. The VIC-Y1 monoclonal antibody binds to a cytoplasmic region of human CD74 and thus cannot be used to detect cell surface expression of this molecule. Applications Reported: This VIC-Y1 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections. Applications Tested: This VIC-Y1 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded human tonsil tissue using low pH antigen retrieval. This antibody can be used at less than or equal to 5 μg/mL.

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen CD74
Anwendungen Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Klassifikation Monoclonal
Klon VIC-Y1
Konzentration 0.5 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with 0.09% sodium azide; pH 7.2
Gen CD74
Gen-Zugriffsnummer P04233
Gen-Alias CD74; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule; Cd74 molecule, major histocompatibility complex, class II invariant chain; class II-associated invariant chain peptide; CLIP; DHLAG; dinucleotide microsatellite; gamma chain of class II antigens; H-2 class II histocompatibility antigen gamma chain; histocompatibility: class II antigens, gamma chain of; HLA class II histocompatibility antigen gamma chain; HLADG; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; ia antigen-associated invariant chain; Ia-associated invariant chain; Ia-GAMMA; Ii; invariant polypeptide of major histocompatibility complex, class II antigen-associated; INVG34; MHC class II-associated invariant chain; MHC HLA-DR gamma chain; p33
Gensymbole CD74
Wirtsspezies Mouse
Reinigungsverfahren Affinity chromatography
Menge 100 μg
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 972
Zielspezies Human
Inhalt und Lagerung 4°C
Produkttyp Antibody
Form Liquid
Isotype IgG1
Mehr anzeigen Weniger anzeigen

For Research Use Only.

Name des Produkts
Wählen Sie ein Thema

Indem Sie auf Absenden klicken, erklären Sie sich damit einverstanden, dass Fisher Scientific sich mit Ihnen in Verbindung setzen kann, um Ihr Feedback in diesem Formular zu bearbeiten. Wir werden Ihre Informationen nicht für andere Zwecke weitergeben. Alle bereitgestellten Kontaktinformationen werden in Übereinstimmung mit unserer Datenschutzrichtlinie aufbewahrt. Datenschutzrichtlinie.