missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Rekombinante Proteine
  4. Invitrogen™ Human CDK11/cyclin C, GST Tag, His Tag Recombinant Protein

Invitrogen™ Human CDK11/cyclin C, GST Tag, His Tag Recombinant Protein

Artikelnummer. p-7180888
Change view
Click to view available options
Menge:
1 mg
10 μg
100 μg
Packungsgröße:
1 Milligramm
10 Mikrogramm
100 Mikrogramm
Artikelnummer. Menge unitSize
15970413 10 μg 10 Mikrogramm
17118825 100 μg 100 Mikrogramm
17158845 1 mg 1 Milligramm
3 options
Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen

Nur für Forschungszwecke. Die Anwendung muss den Produktanweisungen entsprechen.

Artikelnummer. 15970413

Marke: Invitrogen™ A33511

Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!

Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen

Nur für Forschungszwecke. Die Anwendung muss den Produktanweisungen entsprechen.

Beschreibung

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This CDK11/cyclin C recombinant human protein (CDK11: 1-502, cyclin C: 1-283) was expressed in insect cells. CDK11/cyclin C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the LanthaScreen™ Eu Kinase Binding assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Recombinant, Active, Catalytic The gene accession number for CDK11 and cyclin C are NP_055891.1 and NP_005181.2.

Cyclin-dependent kinase 11 (CDK11, and also known as CDK19) and Cyclin C are key players in regulating transcription and cell cycle progression, particularly during apoptosis and cytokinesis. CDK11 exists in two major isoforms, CDK11p46 and CDK11p110, which are generated through alternative splicing and proteolytic processing. Cyclin C partners specifically with the CDK11p46 isoform, forming a complex that is involved in RNA splicing and mediating transcriptional responses necessary for cellular stress responses. CDK11's gene is located on human chromosome 1p36.3-p36.33 and its role in mediating cytokinesis involves phosphorylation of proteins that control the breakdown of the nuclear matrix and spindle formation. Cyclin C, when associated with CDK11, has been shown to have roles in the regulation of transcription factor activity, impacting the transcriptional program during cell cycle checkpoints. Aberrant expression and functioning of the CDK11/Cyclin C complex have been implicated in tumorigenesis, highlighting its importance in cancer biology. Furthermore, CDK11 is essential for maintaining mitochondrial integrity and function, thus further broadening its influence on cellular health beyond mere transcriptional control.
TRUSTED_SUSTAINABILITY

Spezifikation

Zugriffsnummer P24863, Q9BWU1
Konzentration See Label
Zur Verwendung mit (Anwendung) Kinase Assay
Zusammensetzung 50mM HEPES with 100mM NaCl, 20% glycerol, 5mM DTT and no preservative; pH 7.5
Gen-ID (Entrez) 23097, 892
Molekulargewicht 84.9-38.0 kDa
Name Human CDK11/cyclin C, GST Tag, His Tag
pH-Bereich 7.5
Reinigungsverfahren Purified
Menge 10 μg
Lagerungsbedingungen -80°C, Avoid Freeze/Thaw Cycles
Kennzeichnung RUO
Gen-Alias 2700084L06Rik; AI845279; AW228747; bA346C16.3; Cdc2l6; CDC2-related protein kinase 6; Cdk11; Cdk19; CDK8-like cyclin-dependent kinase; cell division cycle 2-like 6 (CDK8-like); cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; cyclin dependent kinase 19; cyclin dependent kinase 19 variant 2; cyclin-dependent kinase (CDC2-like) 11; cyclin-dependent kinase 11; Cyclin-dependent kinase 19; death-preventing kinase; KIAA1028; mKIAA1028
Gebräuchliche Bezeichnung CDK11/cyclin C
Gensymbol CCNC, CDK19
Kinase-Familie CDKs and CHKs
Produkttyp Protein
Konjugat Unconjugated
Spezies Human
Rekombinant Recombinant
Proteinmarkierung GST-tag, His-tag
Sequenz CDK11: 1-502, Cyclin C: 1-283
Inhalt und Lagerung -80°C, Avoid Freeze/Thaw Cycles
Versandbedingung Dry Ice
Expressionssystem Insect cells
Proteinfamilie Kinases & Inhibitors
Proteinform Recombinant, Active, Catalytic
Form Liquid
Mehr anzeigen Weniger anzeigen
Name des Produkts
Wählen Sie ein Thema

Indem Sie auf Absenden klicken, erklären Sie sich damit einverstanden, dass Fisher Scientific sich mit Ihnen in Verbindung setzen kann, um Ihr Feedback in diesem Formular zu bearbeiten. Wir werden Ihre Informationen nicht für andere Zwecke weitergeben. Alle bereitgestellten Kontaktinformationen werden in Übereinstimmung mit unserer Datenschutzrichtlinie aufbewahrt. Datenschutzrichtlinie.