Invitrogen™ Human CDK11/cyclin C, GST Tag, His Tag Recombinant Protein

Cyclin-dependent kinase 11 (CDK11, and also known as CDK19) and Cyclin C are key players in regulating transcription and cell cycle progression, particularly during apoptosis and cytokinesis. CDK11 exists in two major isoforms, CDK11p46 and CDK11p110, which are generated through alternative splicing and proteolytic processing. Cyclin C partners specifically with the CDK11p46 isoform, forming a complex that is involved in RNA splicing and mediating transcriptional responses necessary for cellular stress responses. CDK11's gene is located on human chromosome 1p36.3-p36.33 and its role in mediating cytokinesis involves phosphorylation of proteins that control the breakdown of the nuclear matrix and spindle formation. Cyclin C, when associated with CDK11, has been shown to have roles in the regulation of transcription factor activity, impacting the transcriptional program during cell cycle checkpoints. Aberrant expression and functioning of the CDK11/Cyclin C complex have been implicated in tumorigenesis, highlighting its importance in cancer biology. Furthermore, CDK11 is essential for maintaining mitochondrial integrity and function, thus further broadening its influence on cellular health beyond mere transcriptional control.