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Invitrogen™ CDK8 Polyclonal Antibody
Sheep Polyclonal Antibody
Marke: Invitrogen™ PA5149252
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Beschreibung
Reconstitute at 0.2 mg/mL in sterile PBS.
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 is part of a family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.
Spezifikation
| CDK8 | |
| Polyclonal | |
| Unconjugated | |
| Cdk8 | |
| Cdk8; CDK8 protein kinase; cell division protein kinase 8; Cell division protein kinase 8-like protein; cyclin dependent kinase 8; cyclin-dependent kinase 8; K35; mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; protein kinase K35; RGD1560888; wu:fk95h11 | |
| Sheep | |
| Antigen affinity chromatography | |
| RUO | |
| 1024 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Immunohistochemistry (Paraffin) | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| P49336 | |
| Cdk8 | |
| E. coli-derived recombinant human CDK8, Asn380-Tyr464. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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