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Invitrogen™ CFTR Monoclonal Antibody (CF3)
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Artikelnummer. 11525712
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Menge:
100 μL
Packungsgröße:
100 Mikroliter
Artikelnummer. Menge unitSize
11525712 100 μL 100 Mikroliter
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Artikelnummer. 11525712

Marke: Invitrogen™ MA1935

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Beschreibung

Mouse Monoclonal Antibody

MA1-935 detects cystic fibrosis transmembrane conductance factor (CFTR) in human and mouse tissues. MA1-935 has been successfully used in Western blot, immunofluorescence and immunoprecipitation procedures. By Western blot, this antibody detects a single ~170 kDa protein representing CFTR in T84 whole cell extract. Immunofluorescence staining of CFTR in mouse epithelial cells with MA1-935 results in cell surface staining, consistent with localization at the plasma membrane. This antibody also detects one or more immunologically related proteins in mouse cell line Heb7a that does not contain CFTR mRNA. MA1-935 can also be used to inhibit the epithelial uptake of S. typhi in some mouse cell lines. MA1-935 immunizing peptide corresponds to amino acid residues 103-117 found in the first extracellular loop of human and rabbit CFTR. This sequence is highly conserved in mouse, sheep, cow, and Xenopus laevis.

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen CFTR
Anwendungen Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Klassifikation Monoclonal
Klon CF3
Konzentration Conc. Not Determined
Konjugat Unconjugated
Zusammensetzung Ascites with 0.05% sodium azide
Gen CFTR
Gen-Zugriffsnummer P13569, P26361
Gen-Alias ABC35; Abcc7; ATP Binding Cassette Superfamily C Member 7 (ABCC7); ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; ATP-binding cassette, subfamily c, member 7; AW495489; cAMP-dependent chloride channel; CF; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7; dJ760C5.1; MRP7; RGD1561193; tcag7.78; TNR CFTR; TNR-CFTR
Gensymbole CFTR
Wirtsspezies Mouse
Immunogen Synthetic Peptide: G(103) R I I A S Y D P D N K E E R(117).
Menge 100 μL
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 1080, 12638
Zielspezies Human, Mouse
Inhalt und Lagerung -20°C, Avoid Freeze/Thaw Cycles
Produkttyp Antibody
Form Liquid
Isotype IgM
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