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  6. CRACR2A Mouse anti-Human, Clone: 4C1F5, Proteintech

CRACR2A Mouse anti-Human, Clone: 4C1F5, Proteintech

Artikelnummer. 16848985 Alle ansehen Proteintech Produkte
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150 μL
Packungsgröße:
150 Mikroliter
20 Mikroliter
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16838985 150 μL 150 Mikroliter
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Artikelnummer. 16848985 Lieferant Proteintech Lieferanten-Nr. 667871IG20UL
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Verfügbar ab: 14-09-2026
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Beschreibung

Mouse Monoclonal Antibody

This antibody recognizes both of CRACR2A-c and CRACR2A-a.

CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Spezifikation

Antigen CRACR2A
Anwendungen Western Blot
Klassifikation Monoclonal
Klon 4C1F5
Konzentration 1 mg/mL
Konjugat Unconjugated
Zusammensetzung PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gen CRACR2A
Gen-Zugriffsnummer Q9BSW2
Gen-Alias CRAC channel regulator 2A, CRACR2A, DKFZp686G13246, EFCAB4B, FLJ33046, FLJ33805
Gensymbole CRACR2A
Wirtsspezies Mouse
Immunogen CRACR2A Fusion Protein Ag7525
Reinigungsverfahren Protein G
Menge 20 μL
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 84766
Zielspezies Human
Inhalt und Lagerung -20°C
Produkttyp Antibody
Form Liquid
Isotype IgG1
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