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Invitrogen™ DDR2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marke: Invitrogen™ PA587602
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Beschreibung
Immunogen sequence: NMFAKGVKIF KEVQCYFRSE ASEWEPNAIS FPLVLDDVNP SARFVTVPLH HRMASAIKCQ YHFADTWMMF SEITFQSDAA MYNNSEALPT SPMAPTTYDP MLKVDDSNTR I; Positive Samples: HeLa, A375, HT-1080, Mouse lung, Mouse heart, Mouse kidney, Rat lung; Cellular Location: Cell membrane, Single-pass type I membrane protein.
DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec. DDR2 required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Spezifikation
| DDR2 | |
| Polyclonal | |
| Unconjugated | |
| Ddr2 | |
| AW495251; CD_antigen: CD167b; CD167 antigen-like family member B; CD167b; CD167b antigen; cell migration-inducing protein 20; Ddr2; Discoidin domain receptor 2; discoidin domain receptor family, member 2; discoidin domain receptor tyrosine kinase 2; discoidin domain-containing receptor 2; Discoidin domain-containing receptor tyrosine kinase 2; hydroxyaryl-protein; hydroxyaryl-protein kinase; MIG20a; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; Ntrkr3; receptor protein-tyrosine kinase TKT; RP11-572K18.1; TKT; TYRO10; tyrosine-protein kinase TYRO 10; tyrosine-protein kinase TYRO10; tyrosylprotein kinase | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 18214, 4921, 685781 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot | |
| 2.2 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q16832, Q62371 | |
| Ddr2 | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 290-400 of human DDR2 (NP_0010147961). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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