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Invitrogen™ Dectin 1 Recombinant Rabbit Monoclonal Antibody (7L10N4)
Rabbit Recombinant Monoclonal Antibody
Marke: Invitrogen™ MA558111
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Beschreibung
Immunogen sequence: TMAIWRSNSG SNTLENGYFL SRNKENHSQP TQSSLEDSVT PTKAVKTTGV LSSPCPPNWI IYEKSCYLFS MSLNSWDGSK RQCWQLGSNL LKIDSSNELG FIVKQVSSQP DNSFWIGLSR PQTEVPWLWE DGSTFSSNLF QIRTTATQEN PSPNCVWIHV SVIYDQLCSV PSYSICEKKF SM.
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
Spezifikation
| Dectin 1 | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3 | |
| Q6QLQ4 | |
| Clec7a | |
| Recombinant protein (or fragment). | |
| 20 μL | |
| Primary | |
| Mouse, Rat | |
| Antibody | |
| IgG |
| ELISA, Immunohistochemistry (Paraffin) | |
| 7L10N4 | |
| Unconjugated | |
| Clec7a | |
| Beta-glucan receptor; beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; DECTIN1; dectin-1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; RGD1565140; SCARE2; UNQ539/PRO1082 | |
| Rabbit | |
| Protein A | |
| RUO | |
| 502902, 56644 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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