missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemikalien
  4. Organische Verbindungen
  5. Organische Metallhalogenide
  6. Diclofenac sodium salt

Diclofenac sodium salt

Product Code. 15484939
Change view
Click to view available options
Menge:
5 g
Unit Size:
5 Gramm
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Menge unitSize
15484939 5 g 5 Gramm
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Product Code. 15484939 Supplier Thermo Scientific Alfa Aesar Supplier No. J62609.06
Bulk oder benutzerdefiniertes Format anfordern

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Standard NSAID and cyclooxygenase (COX) inhibitor | CAS: 15307-79-6 | C14H10Cl2NNaO2 | 318.129 g/mol

Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Oxidation of diclofenac sodium produces the metabolite 4′-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

Solubility
Soluble in water (50 mg/ml), PBS pH 7.2 (6 mg/ml), ethanol (∼35 mg/ml), DMF (∼35 mg/ml), DMSO (∼35 mg/ml), methanol (>24 mg/ml), and acetone (6 mg/ml).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 15307-79-6
Summenformel C14H10Cl2NNaO2
Molekulargewicht (g/mol) 318.129
MDL-Nummer MFCD00082251
InChI-Schlüssel KPHWPUGNDIVLNH-UHFFFAOYSA-M
Synonym diclofenac sodium, sodium diclofenac, diclofenac sodium salt, voltaren, solaraze, anthraxiton, prophenatin, allvoran, batafil, delimon
PubChem CID 5018304
ChEBI CHEBI:4509
IUPAC-Name Natrium;2-[2-(2,6-dichloroanilino)phenyl]acetat
SMILES C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]

Specifications

Chemischer Name oder Material Diclofenac sodium salt
Schmelzpunkt 283°C to 285°C
Farbe Weiß
Menge 5 g
UN-Nummer UN2811
Merck Index 14,3081
Löslichkeitsinformationen Soluble in water to 50mg/ml.
Formelmasse 318.14
Physikalische Form Pulver

Safety and Handling

compliance-icons
Product Identifier
  • Diclofenac sodium salt
 Signal Word
  • Gefahr
 Hazard Category
  • Akute Toxizität Kategorie 3
 Hazard Statement
  • H301-Giftig bei Verschlucken.
 Precautionary Statement
  • P301+P310-BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt anrufen
 Supplemental information
  • MIXTURE LIST-Contain: Diclofenac sodium salt
SDS

RUO – Research Use Only

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.