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Invitrogen™ Elezanumab Recombinant Monoclonal Antibody
Recombinant Monoclonal Antibody
477.00 € - 1204.00 €
Spezifikation
| Antigen | Elezanumab |
|---|---|
| Konzentration | 1 mg/mL |
| Inhalt und Lagerung | -20°C, Avoid Freeze/Thaw Cycles |
| Anwendungen | ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance |
| Klassifikation | Recombinant Monoclonal |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|
30284613
|
Invitrogen™
MA558393 |
100 μg |
477.00 €
100 Mikrogramm |
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|
30283670
|
Invitrogen™
MA558394 |
1 mg |
1204.00 €
1 Milligramm |
Log in om dit product te kopen Registreer vandaag om een webaccount aan te maken | |||||
Beschreibung
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
Elezanumab is a biosimilar that targets RGMA. Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.Spezifikation
| Elezanumab | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Recombinant Monoclonal | |
| Lyophilized | |
| IgG1 | |
| Human | |
| ABT-555; AE12-1Y-QL | |
| Antibody |
| 1 mg/mL | |
| ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance | |
| Unconjugated | |
| Human | |
| RUO | |
| 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2 | |
| Primary | |
| Protein A |
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