Estrogen Receptor (SP1) Rabbit Monoclonal Antibody, Epredia™

Beschreibung

Recognizes a protein of 67 kDa, which is identified as estrogen receptor (ER) alpha. The ER gene consists of more than 140kb of genomic DNA divided into 8 exons, and is translated into a protein with six functionally discrete domains, labeled A through F. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.

Host Species: Rabbit

Clone: SP1

Isotype: IgG

Species Reactivity: Human, Mouse and Hamster. Others not tested.

Epitope: C-terminus

Immunogen: Synthetic peptide derived from C-terminal of human estrogen receptor

Molecular Weight: 67 kDa

Positive Control: Breast CA, MCF-7 cells

Cellular Localization: Nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunofluorescence (Not verified)
• Flow Cytometery (Not verified)