Invitrogen™ Felzartamab Recombinant Monoclonal Antibody

Felzartamab is a fully human recombinant immunoglobulin G1 (IgG1) monoclonal antibody (mAb) that targets CD38 on plasma cells. CD38 is a multifunctional enzyme that is widely expressed in both immune and non-hematopoietic cells. It plays a critical role in NAD+ metabolism by converting NAD+ to ADP-ribose and nicotinamide, which are key molecules in cellular signaling and energy metabolism. Structurally, CD38 is a transmembrane glycoprotein with ectoenzyme activity, meaning that its enzymatic functions occur on the outer surface of the cell membrane. CD38's activity is particularly significant in aging, as its expression increases in immune cells due to the senescence-associated secretory phenotype. This elevation in CD38 activity contributes to decreased NAD+ levels, which is associated with various age-related diseases. CD38 has also been identified as a potential therapeutic target for conditions such as renal immune diseases and age-related metabolic decline.