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Invitrogen™ GFR alpha-1 Recombinant Rabbit Monoclonal Antibody (9K10Y0)
Beschreibung
Immunogen sequence: QTTTATTTTA LRVKNKPLGP AGSENEIPTH VLPPCANLQA QKLKSNVSGN THLCISNGNY EKEGLGASSH ITTKSMAAPP SCGLSPLLVL VVTALSTLLS.
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFR-a-1 recently. GFR-a-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFR-a and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
Spezifikation
Spezifikation
| Antigen | GFR alpha-1 |
| Anwendungen | ELISA, Immunohistochemistry (Paraffin), Immunocytochemistry |
| Klassifikation | Recombinant Monoclonal |
| Klon | 9K10Y0 |
| Konzentration | 1.5 mg/mL |
| Konjugat | Unconjugated |
| Zusammensetzung | PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3 |
| Gen | GFRA1 |
| Gen-Zugriffsnummer | P56159, P97785, Q62997 |
| Gen-Alias | AU042498; DKFZp313E1012; DKFZp686J0156; FLJ10561; FLJ31546; GDNF family receptor alpha 1; GDNF family receptor alpha-1; GDNF receptor alpha; GDNF receptor alpha-1; GDNFR; GDNFRA; GDNFR-alpha; GDNFR-alpha-1; gfr alpha 1; GFR alpha-1; GFRA1; GFR-alpha-1; glial cell line derived neurotrophic factor family receptor alpha 1; Glial cell line-derived neurotrophic factor receptor alpha; GPI-linked anchor protein; MGC23045; PI-linked cell-surface accessory protein; RET ligand 1; RET1L; RETL1; TGF-beta-related neurotrophic factor receptor 1; TRNR1 |
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