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Granzyme B Mouse anti-Human, FITC, Clone: GB11, BD
Beschreibung
The GB11 antibody reacts with human granzyme B, a serine protease of approximately 32kDa. Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin. In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes. Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis. Granzyme B may also be involved in the hydrolysis of extracellular matrix components. Detectable levels of granzyme B have been detected in sera from healthy volunteers. The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from the NK cell line.
Host Species: Mouse
Clone: GB11
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human Granzyme B
Intracellular Staining
Spezifikation
Spezifikation
| Antigen | Granzyme B |
| Anwendungen | Flow Cytometry |
| Klassifikation | Monoclonal |
| Klon | GB11 |
| Konjugat | FITC |
| Zusammensetzung | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
| Wirtsspezies | Mouse |
| Immunogen | Human Granzyme B |
| Reinigungsverfahren | Affinity Purified |
| Menge | 100 Tests |
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For Research Use Only.
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