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Granzyme B Mouse anti-Human, FITC, Clone: GB11, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 560211
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Beschreibung
The GB11 antibody reacts with human granzyme B, a serine protease of approximately 32kDa. Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin. In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes. Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis. Granzyme B may also be involved in the hydrolysis of extracellular matrix components. Detectable levels of granzyme B have been detected in sera from healthy volunteers. The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from the NK cell line.
Host Species: Mouse
Clone: GB11
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human Granzyme B
Intracellular Staining
Spezifikation
| Granzyme B | |
| Monoclonal | |
| FITC | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| GB11 | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Human Granzyme B | |
| 100 Tests | |
| Immunology | |
| Human | |
| IgG1 κ |
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