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Beskrivelse
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.
Tekniske data
Tekniske data
| Antigen | HNMT |
| Anwendungen | Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot |
| Klassifikation | Polyclonal |
| Konzentration | 0.45 mg/mL |
| Konjugat | Unconjugated |
| Zusammensetzung | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gen | HNMT |
| Gen-Zugriffsnummer | P50135, Q01984, Q91VF2 |
| Gen-Alias | histamine N methyltransferase, HMT, HNMT, HNMT S1, HNMT S2 |
| Gensymbole | HNMT |
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Produkttitel
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