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Invitrogen™ Human DCC (aa 1334-1431) Control Fragment Recombinant Protein
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Menge:
100 μl
Packungsgröße:
100 Mikroliter
Beschreibung
Highest antigen sequence indentity to the following orthologs: Mouse (98%), Rat (98%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-64420 (PA5-64420. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Spezifikation
Spezifikation
| Zugriffsnummer | P43146 |
| Konzentration | ≥5.0 mg/mL |
| Zur Verwendung mit (Anwendung) | Blocking Assay, Control |
| Zusammensetzung | 1 M urea, PBS with no preservative; pH 7.4 |
| Gen-ID (Entrez) | 1630 |
| Name | Human DCC (aa 1334-1431) Control Fragment |
| Menge | 100 μl |
| Kennzeichnung | RUO |
| Gen-Alias | C030036D22Rik; Colorectal cancer suppressor; colorectal tumor suppressor; CRC18; CRCR1; Dcc; DCC netrin 1 receptor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; IGDCC1; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; MRMV1; Netrin receptor DCC; NTN1R1; putative colorectal tumor suppressor; tumor suppressor protein DCC |
| Gebräuchliche Bezeichnung | DCC |
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