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Gibco™ Human GM-CSF, Animal-Free Recombinant Protein, PeproTech®

Artikelnummer. 17833683
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Menge:
1 mg
100 μg
20 μg
500 μg
Unit Size:
1 Milligramm
100 Mikrogramm
20 Mikrogramm
500 Mikrogramm
Product Code. Menge unitSize
17833683 100 μg 100 Mikrogramm
17833163 1 mg 1 Milligramm
17873283 20 μg 20 Mikrogramm
17843163 500 μg 500 Mikrogramm
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Product Code. 17833683

Brand: Gibco™ AF30003100UG

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620.80 EUR gültig bis 2026-06-30
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Description

Recombinant Protein

Recombinant Human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
TRUSTED_SUSTAINABILITY

Specifications

Zugriffsnummer P04141
Zur Verwendung mit (Anwendung) Functional Assay
Zusammensetzung protein with no preservative
Gen-ID (Entrez) 1437
Molekulargewicht 14.6 kDa
Name Human GM-CSF, Animal-Free
Menge 100 μg
Quelle E. coli
Kennzeichnung RUO
Endotoxin-Konzentration <0.1 EU/ μg
Gen-Alias colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
Gebräuchliche Bezeichnung GM-CSF
Gensymbol CSF2
Biologische Aktivität The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg
Konjugat Unconjugated
Rekombinant Recombinant
Sequenz MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE
Inhalt und Lagerung -20°C
Expressionssystem E. coli
Form Lyophilized
Reinheits- oder Qualitätsgrad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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