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Gibco™ Human Growth Hormone Recombinant Protein, PeproTech®

Artikelnummer. 17871333
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Artikelnummer. Menge unitSize
17871333 100 μg 100 Mikrogramm
17851633 10 μg 10 Mikrogramm
17841033 1 mg 1 Milligramm
17801233 250 μg 250 Mikrogramm
17879992 500 μg 500 Mikrogramm
17840093 50 μg 50 Mikrogramm
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Artikelnummer. 17871333 Leverandør Gibco™ Leverandørnr. 10040100UG

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Beskrivelse

Recombinant Protein

Recombinant Human Growth Hormone is a 22.3 kDa, single, non-glycosylated polypeptide chain containing 192 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The GH1 gene, along with 4 additional related genes, is located at the growth hormone locus on chromosome 17. The five genes share a remarkably high degree of sequence identity. Alternative splicing results in 5 isoforms ranging from approximately 19 kDa to 24 kDa. HGH is produced by the somatotroph cells in the pituitary. It acts through binding to membrane receptors that belong to the cytokine receptor subfamily. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Mutations or deletions in the gene lead to growth hormone deficiency and short stature.
TRUSTED_SUSTAINABILITY

Tekniske data

Zugriffsnummer P01241
Zur Verwendung mit (Anwendung) Functional Assay
Zusammensetzung protein with no preservative
Gen-ID (Entrez) 2688
Molekulargewicht 22.3 kDa
Name Human Growth Hormone
Menge 100 μg
Quelle E. coli
Kennzeichnung RUO
Endotoxin-Konzentration <1 EU/ μg
Gen-Alias dog growth hormone; GH; Gh1; GHB1; GHB5; GHN; GH-N; Growth hormone; growth hormone 1; growth hormone 12; growth hormone B1; growth hormone B5; growth hormone precursor; HGH; hGH-N; IGHD1B; pituitary growth hormone; RNGHGP; Somatotropin
Gebräuchliche Bezeichnung Growth Hormone
Gensymbol Gh1
Biologische Aktivität Determined by its ability to stimulate the proliferation of rat Nb2-11 cells. The expected ED50 is = 0.05 ng/ml, corresponding to a specific activity of = 2 x 10^7 units/mg
Konjugat Unconjugated
Rekombinant Recombinant
Sequenz MFPTIPLSRL FDNAMLRAHR LHQLAFDTYQ EFEEAYIPKE QKYSFLQNPQ TSLCFSESIP TPSNREETQQ KSNLELLRIS LLLIQSWLEP VQFLRSVFAN SLVYGASDSN VYDLLKDLEE GIQTLMGRLE DGSPRTGQIF KQTYSKFDTN SHNDDALLKN YGLLYCFRKD MDKVETFLRI VQCRSVEGSC GF
Inhalt und Lagerung -20°C
Expressionssystem E. coli
Form Lyophilized
Reinheits- oder Qualitätsgrad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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