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Gibco™ Human HB-EGF Recombinant Protein, PeproTech®

Artikelnummer. 17880923
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Artikelnummer. Menge unitSize
17880923 100 μg 100 Mikrogramm
17891733 10 μg 10 Mikrogramm
17860753 1 mg 1 Milligramm
17851033 250 μg 250 Mikrogramm
17810853 500 μg 500 Mikrogramm
17821743 50 μg 50 Mikrogramm
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Artikelnummer. 17880923 Lieferant Gibco™ Lieferanten-Nr. 10047100UG

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Descripción

Recombinant Protein

Recombinant Human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extracellular EGF-like and heparin-binding domains of the full length HB-EGF protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
TRUSTED_SUSTAINABILITY

Especificaciones

Zugriffsnummer Q99075
Zur Verwendung mit (Anwendung) ELISA, Functional Assay, Western Blot
Zusammensetzung protein with no preservative
Gen-ID (Entrez) 1839
Molekulargewicht 9.7 kDa
Name Human HB-EGF
Menge 100 μg
Quelle E. coli
Kennzeichnung RUO
Endotoxin-Konzentration <1 EU/ μg
Gen-Alias AW047313; Diphtheria toxin receptor; Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor); diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); DTR; DT-R; DTS; DTSF; GFHB; hb egf; HBEGF; Hb-egf; Hegfl; heparin binding EGF like growth factor; heparin binding epidermal growth factor-like growth factor; heparin-binding EGF-like growth factor; heparin-binding epidermal -growth - like growth factor; heparin-binding epidermal growth factor; heparin-binding epidermal -growth factor; proheparin-binding EGF-like growth factor
Gebräuchliche Bezeichnung HBEGF
Gensymbol HBEGF
Biologische Aktivität Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg
Konjugat Unconjugated
Rekombinant Recombinant
Sequenz DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGER CHGLSL
Inhalt und Lagerung -20°C
Expressionssystem E. coli
Form Lyophilized
Reinheits- oder Qualitätsgrad ≥ 95% by SDS-PAGE gel and HPLC analyses.
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