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Gibco™ Human Heat Stable bFGF Recombinant Protein

Artikelnummer. 15950877
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Menge:
100 μg
5 μg
50 μg
500 μg
Packungsgröße:
1 Mikrogramm
100 Mikrogramm
5 Mikrogramm
50 Mikrogramm
500 Mikrogramm
Artikelnummer. Menge unitSize
15950877 100 μg 100 Mikrogramm
15900547 500 μg 1 Mikrogramm
16443569 500 μg 500 Mikrogramm
15930547 5 μg 5 Mikrogramm
15940877 50 μg 50 Mikrogramm
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Artikelnummer. 15950877

Marke: Gibco™ PHG0369

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Description

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to a concentration of 1.0 mg/mL. Alternatively, reconstitute at lower concentrations in carrier-containing medium. Do not vortex. Apportion the reconstituted protein into working aliquots and store at -20°C. Make any further dilutions of the reconstituted protein in medium, or buffered solution containing carrier protein, such as PBS with 0.1% BSA. For the 5 μg unit size, reconstitute directly in carrier-containing medium. For other unit sizes, reconstitute to 1.0 mg/mL as follows: 50 μg, reconstitute in 50 μL 100 μg, reconstitute in 100 μL 500 μg, reconstitute in 500 μL Storage: Store the lyophilized protein at -20°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at -20°C (not in a frost-free freezer) for up to 12 months. Avoid repeated freeze-thaw cycles.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
TRUSTED_SUSTAINABILITY

Specifications

Zugriffsnummer P09038
Zur Verwendung mit (Anwendung) Bioactivity
Zusammensetzung 20mM potassium phosphate with 750mM NaCl and no preservative
Gen-ID (Entrez) 2247
Molekulargewicht 19 kDa
Name Human Heat Stable bFGF
Reinigungsverfahren Purified
Menge 100 μg
Lagerungsbedingungen -20°C
Kennzeichnung RUO
Endotoxin-Konzentration <1 EU/μg
Gen-Alias Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Gebräuchliche Bezeichnung FGF2
Gensymbol FGF2
Proteinlänge 155 aa + 20 aa for N-terminal tag for purification purposes
Biologische Aktivität ED50 = 0.6 - 1.1 ng/mL; determined by the dose-dependent proliferation of mouse NIH/3T3 fibroblast cells.
Produkttyp Protein
Konjugat Unconjugated
Spezies Human
Rekombinant Recombinant
Sterilität Sterile
Sequenz 155 aa + 20 aa for N-terminal tag for purification purposes
Inhalt und Lagerung -20°C
Klassifikation Carrier-Free
Aktivität ED50 = 0.6 - 1.1 ng/mL; determined by the dose-dependent proliferation of mouse NIH/3T3 fibroblast cells.
Endotoxin-Gehalt <1 EU/μg
Versandbedingung Approved for shipment on Wet or Dry Ice
Expressionssystem E. coli
Proteinfamilie Growth Factors and Receptors
Form Lyophilized
Forschungskategorie Neurobiology, Oncology, Stem Cell Research, Microbiology, Differentiation, Angiogenesis
Reinheits- oder Qualitätsgrad >95% by SDS-PAGE
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