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  4. Gibco™ Human Klotho Recombinant Protein, PeproTech®

Gibco™ Human Klotho Recombinant Protein, PeproTech®

Artikelnummer. 17801343
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Menge:
100 μg
2 x 500 μg
20 μg
250 μg
5 μg
500 μg
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1 Milligramm
100 Mikrogramm
2 Stück
20 Mikrogramm
250 Mikrogramm
5 Mikrogramm
500 Mikrogramm
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Product Code. 17801343

missing translation for 'mfr': Gibco™ 100535UG

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Description

Recombinant Protein

100-53-1MG will be provided as 2 x 500 μg (100-53-500UG). Recombinant Human Klotho is a glycoprotein of 516 amino acid residues that migrates at an apparent molecular weight of 65-70 kDa by SDS-PAGE analysis under reducing conditions. Recombinant Human Klotho has a calculated molecular weight of 58.6 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
TRUSTED_SUSTAINABILITY

Specifications

Zugriffsnummer Q9UEF7
Zur Verwendung mit (Anwendung) Control, Western Blot Control, Bioactivity
Zusammensetzung Protein with no preservative
Gen-ID (Entrez) 9365
Molekulargewicht 58.6 kDa
Name Human Klotho
Reinigungsverfahren Purified
Menge 5 μg
Quelle CHO cells
Lagerungsbedingungen -20°C
Kennzeichnung RUO
Endotoxin-Konzentration <1 EU/μg
Gen-Alias alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein
Gebräuchliche Bezeichnung Klotho
Gensymbol KL
Biologische Aktivität Determined by the dose-dependent stimulation of the proliferation of murine NIH-3T3 cells. Recombinant Human Klotho is effective in a concentration range of 0.5-2.0 ug/ml
Produkttyp Protein
Konjugat Unconjugated
Rekombinant Recombinant
Sequenz EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGGWQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD VASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGLRYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DHFRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSPRL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPRRMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDFT ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQLLSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKMLLPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYH
Inhalt und Lagerung -20°C
Aktivität Determined by the dose-dependent stimulation of the proliferation of murine NIH-3T3 cells. Recombinant Human Klotho is effective in a concentration range of 0.5-2.0 ug/ml.
Expressionssystem CHO cells
Form Lyophilized
Reinheits- oder Qualitätsgrad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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