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Gibco™ Human Noggin Recombinant Protein, PeproTech®

Artikelnummer. p-7246034
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Menge:
100 μg
2 x 500 μg
20 μg
250 μg
5 μg
50 μg
500 μg
Packungsgröße:
1 Milligramm
100 Mikrogramm
2 Stück
20 Mikrogramm
250 Mikrogramm
5 Mikrogramm
50 Mikrogramm
500 Mikrogramm
Artikelnummer. Menge unitSize
17840123 100 μg 100 Mikrogramm
17880143 2 x 500 μg 1 Milligramm
30087766 2 x 500 μg 2 Stück
17811063 20 μg 20 Mikrogramm
17830873 250 μg 250 Mikrogramm
17850883 500 μg 500 Mikrogramm
17850123 50 μg 50 Mikrogramm
17861183 5 μg 5 Mikrogramm
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Artikelnummer. 17840123

Marke: Gibco™ 12010C100UG

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Recombinant Protein

120-10C-1MG will be provided as 2 x 500 μg (120-10C-500UG). Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains. Monomeric glycosylated noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
TRUSTED_SUSTAINABILITY

Especificaciones

Zugriffsnummer Q13253
Zur Verwendung mit (Anwendung) Control, Bioactivity
Zusammensetzung Protein with no preservative
Gen-ID (Entrez) 9241
Molekulargewicht 46 kDa
Name Human Noggin
Reinigungsverfahren Purified
Menge 100 μg
Quelle HEK293 cells
Lagerungsbedingungen -20°C
Kennzeichnung RUO
Endotoxin-Konzentration <1 EU/μg
Gen-Alias NOG; Noggin; Noggin precursor; noggin; LOW QUALITY PROTEIN: noggin; SYM1; symphalangism 1 (proximal); SYNS1; SYNS1A
Gebräuchliche Bezeichnung Noggin
Gensymbol NOG
Biologische Aktivität Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.
Produkttyp Protein
Konjugat Unconjugated
Rekombinant Recombinant
Sequenz QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC
Inhalt und Lagerung -20°C
Aktivität Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.
Expressionssystem HEK293 cells
Form Lyophilized
Reinheits- oder Qualitätsgrad ≥ 95% by SDS-PAGE gel and HPLC analyses.
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