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Gibco™ Human Osteopontin Recombinant Protein, PeproTech®
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Menge:
1 mg
10 μg
100 μg
250 μg
50 μg
500 μg
Packungsgröße:
1 Milligramm
10 Mikrogramm
100 Mikrogramm
250 Mikrogramm
50 Mikrogramm
500 Mikrogramm
Beschreibung
Recombinant human Osteopontin is a 298 amino acid protein, which, due to glycosylation, migrates at an apparent molecular weight of 60.0-65.0 kDa by SDS-PAGE analysis under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
Spezifikation
Spezifikation
| Zugriffsnummer | P10451 |
| Zur Verwendung mit (Anwendung) | ELISA, Functional Assay, Western Blot |
| Zusammensetzung | protein with no preservative |
| Gen-ID (Entrez) | 6696 |
| Molekulargewicht | 33.7 kDa |
| Name | Human Osteopontin |
| Menge | 100 μg |
| Quelle | HEK293 cells |
| Kennzeichnung | RUO |
| Endotoxin-Konzentration | <1 EU/ μg |
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