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Gibco™ Human PDGF-BB Recombinant Protein, PeproTech®

Artikelnummer. 17821023
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50 μg
500 μg
Packungsgröße:
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Artikelnummer. Menge unitSize
17821023 50 μg 50 Mikrogramm
17880383 100 μg 100 Mikrogramm
17850403 10 μg 10 Mikrogramm
17839912 1 mg 1 Milligramm
17870883 250 μg 250 Mikrogramm
17831333 2 μg 2 Mikrogramm
17880083 500 μg 500 Mikrogramm
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Codice prodotto. 17821023 Fornitore Gibco™ N. del fornitore 10014B50UG

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Descrizione

Recombinant Protein

Recombinant Human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two beta chains (218 total amino acids). This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
TRUSTED_SUSTAINABILITY

Specifica

Zugriffsnummer P01127
Zur Verwendung mit (Anwendung) ELISA, Functional Assay, Western Blot
Zusammensetzung protein with no preservative
Gen-ID (Entrez) 5155
Molekulargewicht 24.3 kDa
Name Human PDGF-BB
Menge 50 μg
Quelle E. coli
Kennzeichnung RUO
Endotoxin-Konzentration <1 EU/ μg
Gen-Alias becaplermin; c-sis; FLJ12858; H-PDGF-BB; IBGC5; PDGF; pdgf protein; PDGF subunit B; PDGF, B chain; PDGF2; PDGF-2; PDGFB; PDGF-B; platelet derived growth factor subunit B; platelet derived growth factor, B polypeptide; platelet-derived growth factor 2; platelet-derived growth factor B; platelet-derived growth factor B chain; platelet-derived growth factor beta; platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor subunit B; platelet-derived growth factor, beta polypeptide (oncogene SIS); Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis); proto-oncogene c-Sis; Sis; SSV
Gebräuchliche Bezeichnung PDGF-BB
Gensymbol PDGFB
Biologische Aktivität Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells.The expected ED50 for this effect is 1.0-3.0 ng/ml
Konjugat Unconjugated
Rekombinant Recombinant
Sequenz SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT
Inhalt und Lagerung -20°C
Expressionssystem E. coli
Form Lyophilized
Reinheits- oder Qualitätsgrad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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