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Gibco™ Human TL-1A, Animal-Free Recombinant Protein, PeproTech®

Artikelnummer. 17853613
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Menge:
1 mg
100 μg
20 μg
500 μg
Packungsgröße:
1 Milligramm
100 Mikrogramm
20 Mikrogramm
500 Mikrogramm
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Artikelnummer. Menge unitSize
17853613 100 μg 100 Mikrogramm
17883293 1 mg 1 Milligramm
17803803 20 μg 20 Mikrogramm
17813563 500 μg 500 Mikrogramm
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Artikelnummer. 17853613 Lieferant Gibco™ Lieferanten-Nr. AF31023100UG

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Beschreibung

Recombinant Protein

Recombinant Human TL-1A is a 22.1 kDa polypeptide of 195 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.
TRUSTED_SUSTAINABILITY

Spezifikation

Zugriffsnummer O95150
Zur Verwendung mit (Anwendung) Functional Assay
Zusammensetzung protein with no preservative
Gen-ID (Entrez) 9966
Molekulargewicht 22.1 kDa
Name Human TL-1 A, Animal-Free
Menge 100 μg
Quelle E. coli
Kennzeichnung RUO
Endotoxin-Konzentration <0.1 EU/ μg
Gen-Alias bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15); MGC129934; MGC129935; TL1; TL1A; TNF ligand-related molecule 1; TNF superfamily ligand TL1A; TNFSF15; TNLG1B; tumor necrosis factor (ligand) superfamily member 15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand 1 B; tumor necrosis factor ligand superfamily member 15; Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form; tumor necrosis factor superfamily member 15; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor; vascular endothelial growth inhibitor-192 A; Vegi; VEGI192A
Gebräuchliche Bezeichnung TL1A
Gensymbol TNFSF15
Biologische Aktivität Determined by its ability to stimulate IFN-gamma production by human PBMC co-stimulated with Human IL-12 and Human IL-18.
Konjugat Unconjugated
Rekombinant Recombinant
Sequenz MQLRAQGEAS VQFQALKGQE FAPSHQQVYA PLRADGDKPR AHLTVVRQTP TQHFKNQFPA LHWEHELGLA FTKNRMNYTN KFLLIPESGD YFIYSQVTFR GMTSECSEIR QAGRPNKPDS ITVVITKVTD SYPEPTQLLM GTKSVCEVGS NWFQPIYLGA MFSLQEGDKL MVNVSDISLV DYTKEDKTFF GAFLL
Inhalt und Lagerung -20°C
Expressionssystem E. coli
Form Lyophilized
Reinheits- oder Qualitätsgrad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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